SCHEMBL919042

SCHEMBL919042

O=C(O)c1ccc(C=C2SC(=S)N(c3cccc(C(F)(F)F)c3)C2=O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CFTR P13569 15/20 1.00
NLRP3 Q96P20 4/20 1.00
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
DUSP22 Q9NRW4 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1881897 1.00 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL29496311 1.00 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL29577183 1.00 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL30292040 1.00 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL1326698 1.00 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL24217771 0.91 CFTR (0.83) CFTRNLRP3MEN1KMT2A
SCHEMBL1882597 0.91 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL1882593 0.91 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL1882595 0.91 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22
SCHEMBL1880600 0.90 CFTR (1.00) CFTRNLRP3MEN1KMT2ADUSP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 300 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220280514-A1 METHODS OF TREATING BILE ACID DIARRHEA UNIV CALIFORNIA (US) 2022-09-08 US claimed
CN-113384704-B Application of CFTR-Dvl 2-beta-catenin pathway inhibitor in leukemia and product 四川大学华西第二医院 2022-05-03 CN claimed
EP-3982972-A1 METHODS OF TREATING BILE ACID DIARRHEA The Regents of the University of California (US) 2022-04-20 EP claimed
US-20220088026-A1 METHODS OF TREATING TYROSINE KINASE INHIBITOR-INDUCED DIARRHEA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-03-24 US claimed
US-9066938-B2 GPBP-1 inhibition and its therapeutic use Fibrostein, S.L. (ES) 2015-06-30 US claimed
EP-2866835-A1 GPBP-1 INHIBITION AND ITS THERAPEUTIC USE Fibrostatin, S.L. (ES) 2015-05-06 EP claimed
WO-2014006020-A1 GPBP-1 INHIBITION AND ITS THERAPEUTIC USE FIBROSTATIN, S.L. (ES) 2014-01-09 WO claimed
US-20140005134-A1 GPBP-1 inhibition and its therapeutic use UNIVERSITAT DE VALENCIA (ES) 2014-01-02 US claimed
WO-2009079373-A2 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-06-25 WO claimed
US-7235573-B2 Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-06-26 US claimed
EP-1549321-A4 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF UNIV CALIFORNIA (US) 2007-05-23 EP claimed
EP-1549321-A2 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-07-06 EP claimed
US-20040235800-A1 Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-11-25 US claimed
WO-2004028480-A2 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2004-04-08 WO claimed
US-20040063695-A1 Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE 2004-04-01 US claimed
WO-2026106983-A1 SYNERGISTIC NHEJ INHIBITION TO OBTAIN ENRICHMENT FREE SEQUENTIAL INSERTION OF GENES > 4 KB RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) 2026-05-21 WO disclosed
US-20260125686-A1 COMPOSITIONS AND METHODS FOR MODULATION OF CFTR CYSTIC FIBROSIS FOUND (US) 2026-05-07 US disclosed
US-20040235800-A1 Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-11-25 US disclosed
WO-2004028480-A2 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2004-04-08 WO disclosed
US-20040063695-A1 Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE 2004-04-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220088026-A1 METHODS OF TREATING TYROSINE KINASE INHIBITOR-INDUCED DIARRHEA CFTR, LCK, ABL1 CFTR 1/4885NLRP3 2575/4885MEN1 3449/4885
US-20040235800-A1 Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof CFTR, TMEM205, TMEM33 CFTR 1/4885NLRP3 444/4885MEN1 4413/4885
US-20220280514-A1 METHODS OF TREATING BILE ACID DIARRHEA SLC10A2, CFTR, SLC26A4 CFTR 2/4885NLRP3 1901/4885MEN1 4452/4885
US-20140005134-A1 GPBP-1 inhibition and its therapeutic use ABCC1, ABCC8, ABCB1 CFTR 530/4885NLRP3 4283/4885MEN1 4339/4885
US-20040063695-A1 Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof CFTR, TMEM205, TMEM33 CFTR 1/4885NLRP3 444/4885MEN1 4413/4885
US-20260125686-A1 COMPOSITIONS AND METHODS FOR MODULATION OF CFTR CFTR, UPF1, RNGTT CFTR 1/4885NLRP3 1294/4885MEN1 3374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.