Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 5/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662742 | 0.83 | RIPK1 (0.64) | RIPK1PTGESPYCR1MAOBTAAR1 | |
| SCHEMBL9063113 | 0.79 | HSD11B1 (0.48) | RIPK1ALOX5PTGS1PTGS2MAOB | |
| SCHEMBL23819869 | 0.79 | RIPK1 (0.75) | RIPK1PTGESPYCR1 | |
| SCHEMBL1436622 | 0.77 | ALOX5 (0.70) | RIPK1ALOX5PTGS1PTGS2MEN1 | |
| SCHEMBL2634610 | 0.76 | RIPK1 (0.64) | RIPK1PTGESPYCR1TAAR1HCAR2 | |
| SCHEMBL67173 | 0.76 | RIPK1 (0.56) | RIPK1PTGESPYCR1TAAR1HCAR2 | |
| SCHEMBL9707266 | 0.74 | ALOX5 (0.61) | PTGESALOX5PTGS1PTGS2 | |
| SCHEMBL9062790 | 0.74 | CYP1A2 (0.57) | PYCR1MAOBMAOAMEN1HTT | |
| SCHEMBL9192563 | 0.74 | PTGES (0.56) | PTGESALOX5PTGS1PTGS2 | |
| SCHEMBL609893 | 0.74 | MAOB (0.51) | RIPK1MAOBTAAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468281-B1 | Substituted phenylacetylenes, pharmaceuticals containing them and methods for the preparation of these compounds and pharmaceuticals | GRUENENTHAL GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5202349-A | Lipoxygenase inhibitors, antiasthatics | GRUENENTHAL GMBH (DE) | 1993-04-13 | — | — | US | disclosed |
| EP-0468281-A1 | Substituted phenylacetylenes, pharmaceuticals containing them and methods for the preparation of these compounds and pharmaceuticals | Grünenthal GmbH (DE) | 1992-01-29 | — | — | EP | disclosed |