Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.81 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.81 |
| ▸ | CFTR | P13569 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194373 | 0.90 | AGTR1 (1.00) | AGTR1AGTR2 | |
| SCHEMBL9271577 | 0.85 | AGTR1 (0.80) | AGTR1AGTR2DRD2TBXA2RKDM4E | |
| SCHEMBL9688902 | 0.84 | AGTR2 (0.75) | AGTR1AGTR2KDM4E | |
| SCHEMBL9275378 | 0.80 | AGTR1 (0.78) | AGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL23507217 | 0.79 | VCAM1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL9198105 | 0.77 | AGTR1 (0.78) | AGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL7998324 | 0.75 | VCAM1 (0.54) | — | |
| SCHEMBL11602247 | 0.74 | VCAM1 (0.53) | — | |
| SCHEMBL9200766 | 0.74 | AGTR1 (0.80) | AGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL9201172 | 0.74 | DRD2 (0.78) | AGTR1AGTR2DRD2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399732-B1 | Benzimidazole derivatives | ZENECA LTD (GB) | 1995-07-26 | — | — | EP | disclosed |
| US-5171748-A | For hypertension, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-15 | — | — | US | disclosed |
| EP-0399732-A1 | Benzimidazole derivatives | ZENECA LIMITED (GB) | 1990-11-28 | — | — | EP | disclosed |