SCHEMBL919892

SCHEMBL919892

Cc1ccsc1Oc1ccc(CNC(=O)c2cccnc2N)cc1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAPK8 P45983 1/20 0.49
▸ HPGD P15428 4/20 0.48
▸ LMNA P02545 2/20 0.48
▸ SMN1; SMN2 Q16637 2/20 0.48
▸ POLB P06746 1/20 0.46
▸ EGLN1 Q9GZT9 1/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ MAPT P10636 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ PIK3CD O00329 1/20 0.44
▸ ALDH1A1 P00352 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL919198 0.89 HPGD (0.51) MAPK8HPGDPOLBMEN1MAPT
SCHEMBL922454 0.89 HPGD (0.53) MAPK8HPGDLMNASMN1; SMN2POLB
SCHEMBL919888 0.85 ALDH1A1 (0.48) MAPK8HPGDLMNASMN1; SMN2POLB
SCHEMBL922484 0.85 HPGD (0.62) MAPK8HPGDLMNASMN1; SMN2POLB
SCHEMBL920723 0.84 ADORA2A (0.43) HPGDSMN1; SMN2POLBEGLN1ALDH1A1
SCHEMBL921013 0.84 HPGD (0.50) MAPK8HPGDLMNASMN1; SMN2POLB
SCHEMBL920673 0.84 HPGD (0.48) MAPK8HPGDLMNASMN1; SMN2POLB
SCHEMBL919655 0.84 MAPK8 (0.52) MAPK8HPGDLMNASMN1; SMN2POLB
SCHEMBL919966 0.83 MAPK14 (0.61) MAPK8HPGDLMNASMN1; SMN2POLB
SCHEMBL921056 0.83 LMNA (0.57) MAPK8HPGDLMNASMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 — — US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK8 2313/4885HPGD 1273/4885LMNA 4812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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