Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11994159 | 0.83 | POLB (0.49) | HTR7CES2CES1PTGS2POLB | |
| SCHEMBL14604997 | 0.80 | ALOX5 (0.44) | HTR7CES2CES1PTGS2POLB | |
| SCHEMBL11994148 | 0.79 | HTR7 (0.50) | HTR7PTGS2POLBGAA | |
| SCHEMBL8553233 | 0.79 | CES2 (0.42) | CES2CES1PTGS2PTPN1NPC1 | |
| SCHEMBL11568766 | 0.78 | HTR7 (0.40) | HTR7CES2CES1POLBGAA | |
| SCHEMBL14288473 | 0.78 | ESR1 (0.52) | HTR7POLBGAA | |
| SCHEMBL9377885 | 0.77 | PTPN1 (0.48) | HTR7CES2CES1PTGS2PTPN1 | |
| SCHEMBL5674623 | 0.77 | CES2 (0.41) | CES2CES1PTGS2PTPN1NPC1 | |
| SCHEMBL11399503 | 0.77 | MTNR1A (0.41) | CES2CES1PTGS2POLBGAA | |
| SCHEMBL1226475 | 0.76 | MTNR1A (0.52) | PSMB1PSMB5PSMB2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354539-B1 | Antiinflammatory carbinoloimidazoles | DU PONT MERCK PHARMA (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0354539-A2 | Antiinflammatory carbinoloimidazoles | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-02-14 | — | — | EP | disclosed |
| US-4859693-A | Antiinflammatory carbinoloimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-22 | — | — | US | disclosed |