Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377208 | 0.87 | MEN1 (0.46) | TSHRMEN1KMT2ANPSR1TP53 | |
| SCHEMBL9543443 | 0.86 | TSHR (0.43) | TSHRMEN1KMT2ANPSR1TP53 | |
| SCHEMBL9205403 | 0.85 | MEN1 (0.44) | TSHRMEN1KMT2ANPSR1TP53 | |
| SCHEMBL9541768 | 0.85 | ALDH1A1 (0.42) | TSHRMEN1KMT2ANPSR1TP53 | |
| SCHEMBL9541755 | 0.82 | CYP1A2 (0.45) | TSHRMEN1KMT2ANPSR1REN | |
| SCHEMBL9542202 | 0.82 | MEN1 (0.47) | TSHRMEN1KMT2ANPSR1TP53 | |
| SCHEMBL9542239 | 0.82 | TSHR (0.42) | TSHRNPSR1TP53HTTSLC6A9 | |
| SCHEMBL9541760 | 0.79 | TUBB4A (0.51) | MEN1KMT2ASLC6A9MAPT | |
| SCHEMBL9540839 | 0.79 | TP53 (0.41) | TSHRMEN1KMT2ANPSR1TP53 | |
| SCHEMBL9208637 | 0.79 | SLC6A9 (0.44) | MEN1KMT2ANPSR1HTTSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344414-B1 | 5-Substitued imidazo[4,5-c]pyridines | SEARLE & CO (US) | 1994-10-12 | — | — | EP | claimed |
| EP-0680478-A1 | N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE 4H-IMIDAZO 4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-11-08 | — | — | EP | disclosed |
| EP-0670838-A1 | SUBSTITUTED-PHENYL(N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE)-1H/3H-IMIDAZO 4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-09-13 | — | — | EP | disclosed |
| EP-0404797-B1 | 1H/3H-[4-(N,N-CYCLOALKYL AND/OR BRANCHED-ALKYLCARBOXAMIDO) -BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | SEARLE & CO (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994029307-A1 | PYRROLO[3,2-B]PYRIDINYLALKYL BENZAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5360907-A | Platelet activating factor | G.D. SEARLE & CO. (US) | 1994-11-01 | — | — | US | disclosed |
| US-5359073-A | Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists | G. D. SEARLE & CO. (US) | 1994-10-25 | — | — | US | disclosed |
| EP-0344414-B1 | 5-Substitued imidazo[4,5-c]pyridines | SEARLE & CO (US) | 1994-10-12 | — | — | EP | disclosed |
| WO-1994017063-A1 | N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE 4H-IMIDAZO[4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1994-08-04 | — | — | WO | disclosed |
| WO-1994012500-A1 | SUBSTITUTED-PHENYL(N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE)-1H/3H-IMIDAZO[4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1994-06-09 | — | — | WO | disclosed |
| US-5302601-A | Useful in the treatment of diseases mediated by platelet activating factor | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5262426-A | Treatment of cardiovascular disorders, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-11-16 | — | — | US | disclosed |
| US-5223539-A | Antagonist of platelet activating factor | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| WO-1993010077-A1 | N,N-DI-ALKYL(PHENOXY)BENZAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |
| US-5208242-A | 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0404797-A4 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL)IMIDAZO 4,5-C)PYRIDINES AS PAF ANTAGONISTS | — | 1992-01-22 | — | — | EP | disclosed |
| EP-0404797-A1 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO 4,5-c]PYRIDINES AS PAF ANTAGONISTS. | SEARLE & CO (US) | 1991-01-02 | — | — | EP | disclosed |
| WO-1989008653-A1 | 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1989-09-21 | — | — | WO | disclosed |