Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19664385 | 0.86 | KMT2A (0.43) | ACACBL3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL5132689 | 0.85 | MAPT (0.48) | ACACBL3MBTL1ALDH1A1TSHRMAPT | |
| SCHEMBL9191894 | 0.85 | TSHR (0.39) | ACACBTSHRMAPTKMT2AACACA | |
| SCHEMBL11277376 | 0.79 | MAPT (0.53) | ACACBL3MBTL1MAPTKMT2ALMNA | |
| SCHEMBL9199729 | 0.79 | ALDH1A1 (0.38) | ACACBL3MBTL1ALDH1A1TSHRMAPT | |
| SCHEMBL15899401 | 0.77 | LMNA (0.47) | L3MBTL1ALDH1A1TSHRMAPTKMT2A | |
| SCHEMBL16732335 | 0.76 | LMNA (0.46) | L3MBTL1ALDH1A1TSHRMAPTKMT2A | |
| SCHEMBL1228643 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TSHRMAPTKMT2ALMNA | |
| SCHEMBL9197151 | 0.75 | LMNA (0.41) | ACACBL3MBTL1ALDH1A1TSHRMAPT | |
| SCHEMBL8096967 | 0.75 | ACACB (0.42) | ACACBKMT2ALMNAACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278452-B1 | 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds | HOECHST AG (DE) | 1995-05-24 | — | — | EP | disclosed |
| EP-0278452-A2 | 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-17 | — | — | EP | disclosed |