Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202908 | 1.00 | PLA2G2A (0.45) | PLA2G2ACYP4F2CYP4A11CYSLTR1MRGPRX4 | |
| SCHEMBL9203804 | 0.86 | PLA2G2A (0.50) | PLA2G2ACYP4F2CYP4A11 | |
| SCHEMBL9203800 | 0.86 | PLA2G2A (0.50) | PLA2G2ACYP4F2CYP4A11 | |
| SCHEMBL9210323 | 0.78 | LTB4R (0.49) | PLA2G2ALTB4R | |
| SCHEMBL9207699 | 0.78 | PLA2G2A (0.47) | PLA2G2ACYP4F2CYP4A11CYSLTR1LTB4R | |
| SCHEMBL9207543 | 0.78 | CYSLTR2 (0.40) | PLA2G2ACYSLTR1CYSLTR2 | |
| SCHEMBL9207540 | 0.78 | CYSLTR2 (0.40) | PLA2G2ACYSLTR1CYSLTR2 | |
| SCHEMBL9747317 | 0.77 | ALDH1A1 (0.37) | PLA2G2ACYSLTR1CYSLTR2 | |
| SCHEMBL9209480 | 0.77 | CYSLTR2 (0.37) | CYSLTR1CYSLTR2 | |
| SCHEMBL9209485 | 0.77 | CYSLTR2 (0.37) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399818-B1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC (CA) | 1995-08-16 | — | — | EP | disclosed |
| US-5204358-A | Antiallergens; antiinflammatory agents; treatment of asthma, rhinitis, bronchitis and skin diseases | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| US-5104882-A | Leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-04-14 | — | — | US | disclosed |
| EP-0399818-A1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC. (CA) | 1990-11-28 | — | — | EP | disclosed |