SCHEMBL920601

SCHEMBL920601

Fc1[c]ccc(Oc2ccc(C(F)(F)F)cn2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.56
MAPK1 P28482 1/20 0.54
MAPT P10636 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
LMNA P02545 1/20 0.47
LIPE Q05469 5/20 0.46
KMT2A Q03164 1/20 0.46
BCHE P06276 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
TSHR P16473 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
RAB9A P51151 1/20 0.44
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.44
SCN9A Q15858 4/20 0.44
HPGD P15428 1/20 0.44
SCN10A Q9Y5Y9 1/20 0.42
SCN7A Q01118 1/20 0.42
KCNH2 Q12809 1/20 0.42
SCN5A Q14524 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921136 0.80 MAPT (0.57) THRBMAPK1MAPTNPSR1LMNA
SCHEMBL11351938 0.78 MAPT (0.69) THRBMAPK1MAPTNPSR1LMNA
SCHEMBL919739 0.77 RAB9A (0.60) MAPTNPSR1LMNALIPEKMT2A
SCHEMBL31360353 0.74 THRB (0.67) THRBMAPK1MAPTNPSR1LMNA
SCHEMBL31694849 0.74 THRB (0.59) THRBMAPK1MAPTNPSR1LMNA
SCHEMBL9507549 0.73 MAPK1 (0.64) THRBMAPK1MAPTNPSR1LMNA
Hydrochloric Acid SCHEMBL31694888 0.73 THRB (0.58) THRBMAPK1MAPTNPSR1LMNA
SCHEMBL921936 0.73 TLR4 (0.41) SCN9A
SCHEMBL1417238 0.73 THRB (0.69) THRBMAPK1MAPTNPSR1LMNA
SCHEMBL5651111 0.72 MAPK1 (0.67) THRBMAPK1MAPTNPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110201649-A1 AGRICULTURAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-08-18 US disclosed
EP-2345328-A1 COMPOSITION FOR AGRICULTURAL USE Sumitomo Chemical Company, Limited (JP) 2011-07-20 EP disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 THRB 1345/4885MAPK1 1392/4885MAPT 695/4885
US-20110201649-A1 AGRICULTURAL COMPOSITION H1-0, H1-3, H1-2 THRB 2399/4885MAPK1 2121/4885MAPT 1422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.