Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213007 | 0.91 | GRM5 (0.38) | HSD11B1ACHEHTR2ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL9216230 | 0.90 | GRM5 (0.37) | HSD11B1ACHEHTR2ADRD2HTR7 | |
| SCHEMBL9210283 | 0.81 | SIGMAR1 (0.42) | HSD11B1GRIN2BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL9216937 | 0.78 | SIGMAR1 (0.39) | HSD11B1GRIN2BSIGMAR1 | |
| SCHEMBL9213552 | 0.78 | ALDH1A1 (0.38) | ACHEHTR2AHTR1ATMEM97 | |
| SCHEMBL9215931 | 0.76 | HRH3 (0.38) | ACHE | |
| SCHEMBL9739700 | 0.76 | GRM5 (0.41) | ACHEGRIN2BSIGMAR1HTR1A | |
| SCHEMBL9214452 | 0.76 | GRM5 (0.40) | — | |
| SCHEMBL9212426 | 0.76 | PDE6D (0.39) | ACHE | |
| SCHEMBL9214068 | 0.76 | HTR1D (0.42) | DRD2HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |