Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9216937 | 0.93 | SIGMAR1 (0.39) | SIGMAR1HSD11B1GRIN2BGRIN1HRH3 | |
| SCHEMBL9213007 | 0.84 | GRM5 (0.38) | SIGMAR1HSD11B1GRIN2BGRIN1HRH3 | |
| Hydrochloric Acid SCHEMBL9216230 | 0.82 | GRM5 (0.37) | SIGMAR1HSD11B1GRIN2BGRIN1HRH3 | |
| Hydrochloric Acid SCHEMBL9740211 | 0.81 | HRH3 (0.43) | HRH3 | |
| SCHEMBL9206331 | 0.81 | HSD11B1 (0.38) | SIGMAR1HSD11B1GRIN2B | |
| SCHEMBL9216662 | 0.78 | HRH3 (0.43) | HRH3 | |
| Hydrochloric Acid SCHEMBL9216765 | 0.78 | HRH3 (0.41) | HRH3 | |
| SCHEMBL9211758 | 0.78 | PDE4B (0.48) | SIGMAR1HSD11B1 | |
| SCHEMBL9212427 | 0.77 | ABCB1 (0.48) | — | |
| SCHEMBL9204602 | 0.76 | HSD11B1 (0.37) | SIGMAR1HSD11B1GRIN2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |