Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622686 | 0.88 | KCNH2 (0.41) | KCNH2PYCR1MMP2MMP12ACACB | |
| SCHEMBL25864597 | 0.80 | CYP3A4 (0.41) | KCNH2PYCR1MMP2HPGDACACB | |
| SCHEMBL5243364 | 0.80 | NPSR1 (0.53) | KCNH2MMP2MMP12NPSR1GAA | |
| SCHEMBL4623625 | 0.79 | HTT (0.37) | KCNH2PYCR1MMP2MMP12HPGD | |
| SCHEMBL13293354 | 0.77 | KCNH2 (0.38) | KCNH2MMP2MMP12NPSR1GAA | |
| SCHEMBL26675160 | 0.76 | PYCR1 (0.37) | KCNH2PYCR1ACACBLMNA | |
| SCHEMBL9158372 | 0.74 | GABRP (0.44) | KCNH2PYCR1MMP2MMP12NPSR1 | |
| Ether SCHEMBL6687627 | 0.73 | CYP2A6 (0.50) | NPSR1GAANPC1HPGDRAB9A | |
| SCHEMBL8623675 | 0.72 | GABRP (0.43) | KCNH2PYCR1MMP2MMP12NPSR1 | |
| SCHEMBL457693 | 0.72 | NQO1 (0.58) | ACACBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641338-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES AND INTERMEDIATES | PFIZER INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993002079-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES AND INTERMEDIATES | PFIZER INC. (US) | 1993-02-04 | — | — | WO | disclosed |