Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204602 | 0.83 | HSD11B1 (0.37) | SIGMAR1TMEM97HSD11B1 | |
| Hydrochloric Acid SCHEMBL9216937 | 0.81 | SIGMAR1 (0.39) | PDE4BSIGMAR1HSD11B1 | |
| SCHEMBL9212427 | 0.80 | ABCB1 (0.48) | ABCB1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Hydrochloric Acid SCHEMBL9208180 | 0.79 | PDE4B (0.58) | PDE4BABCB1PDE4DBCHE | |
| SCHEMBL9210283 | 0.78 | SIGMAR1 (0.42) | SIGMAR1HSD11B1 | |
| SCHEMBL9212261 | 0.77 | ABCB1 (0.49) | ABCB1HTR7DRD3 | |
| SCHEMBL9214611 | 0.77 | PTGER2 (0.48) | PDE4BBCHE | |
| SCHEMBL9624149 | 0.75 | KDM4E (0.46) | PDE4BABCB1EBPSIGMAR1TMEM97 | |
| SCHEMBL9217614 | 0.75 | ACHE (0.50) | ABCB1HTR7DRD4BCHE | |
| Hydrochloric Acid SCHEMBL10644273 | 0.74 | PDE4B (0.66) | PDE4BABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |