Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9210396 | 0.84 | ALDH1A1 (0.43) | ALDH1A1HTTKDM4ENPSR1KMT2A | |
| SCHEMBL8470246 | 0.82 | CES2 (0.45) | CES2ACHECES1ALDH1A1RAB9A | |
| SCHEMBL7292399 | 0.80 | CES2 (0.43) | CES2ACHECES1ALDH1A1RAB9A | |
| SCHEMBL9206801 | 0.79 | ALDH1A1 (0.45) | ALDH1A1RAB9AKDM4ELMNAGAA | |
| SCHEMBL248344 | 0.78 | NPSR1 (0.44) | ALDH1A1HTTKDM4EL3MBTL1NPSR1 | |
| SCHEMBL248343 | 0.78 | NPSR1 (0.44) | ALDH1A1HTTKDM4EL3MBTL1NPSR1 | |
| SCHEMBL7319630 | 0.78 | ALDH1A1 (0.47) | CES2ACHECES1ALDH1A1RAB9A | |
| SCHEMBL2080613 | 0.77 | ALDH1A1 (0.47) | ALDH1A1HTTRAB9AKDM4EL3MBTL1 | |
| SCHEMBL7328793 | 0.76 | L3MBTL1 (0.47) | CES2ACHECES1ALDH1A1RAB9A | |
| SCHEMBL7319642 | 0.76 | SMN1; SMN2 (0.42) | CES2ACHECES1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368652-B1 | Imidazoquinoxalines and their preparation | NOVO NORDISK AS (DK) | 1995-03-01 | — | — | EP | disclosed |
| US-4999353-A | Chemical process for the preparation of imidazo-quinoxalines and intermediates for use in the process | NOVO NORDISK A/S (DK) | 1991-03-12 | — | — | US | disclosed |
| EP-0368652-A1 | Imidazoquinoxalines and their preparation | NOVO NORDISK A/S (DK) | 1990-05-16 | — | — | EP | disclosed |