Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 4/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220670 | 0.82 | ROCK2 (0.36) | CPT1AROCK2ROCK1PDE4DLMNA | |
| SCHEMBL7468218 | 0.81 | AVPR1A (0.40) | HTTMAPTTSHR | |
| SCHEMBL9218597 | 0.79 | HPGD (0.37) | CPT1AROCK2ROCK1PDE4DLMNA | |
| SCHEMBL9217252 | 0.78 | HTT (0.35) | THRBHTTSMN1; SMN2LMNAMAPT | |
| SCHEMBL9221306 | 0.74 | IDH1 (0.34) | CPT1AKMT2AMEN1MAPT | |
| SCHEMBL9211589 | 0.73 | MAPT (0.37) | HTTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL9219603 | 0.73 | ACLY (0.33) | CPT1AROCK2ROCK1 | |
| SCHEMBL9218306 | 0.73 | ACLY (0.33) | CPT1AROCK2ROCK1KMT2ANPC1 | |
| SCHEMBL9217235 | 0.72 | NPSR1 (0.35) | THRBHTTKMT2AMEN1POLB | |
| SCHEMBL9220003 | 0.72 | ANO1 (0.37) | ROCK2ROCK1PDE4DHDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-12-20 | — | — | EP | disclosed |