Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207731 | 0.83 | SIGMAR1 (0.43) | CYP24A1SIGMAR1 | |
| SCHEMBL9740712 | 0.77 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL9739719 | 0.74 | MTNR1B (0.37) | LMNAMAPTKMT2AALDH1A1GAA | |
| SCHEMBL9205099 | 0.73 | HRH3 (0.48) | KMT2AALDH1A1 | |
| SCHEMBL29571633 | 0.70 | CYP2D6 (0.53) | KMT2AALDH1A1L3MBTL1PKM | |
| SCHEMBL19859670 | 0.70 | CYP2D6 (0.53) | KMT2AALDH1A1L3MBTL1PKM | |
| SCHEMBL19859669 | 0.70 | CYP2D6 (0.53) | KMT2AALDH1A1L3MBTL1PKM | |
| SCHEMBL28106795 | 0.69 | ALDH1A1 (0.40) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL16797311 | 0.68 | CYP2D6 (0.44) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL4225647 | 0.68 | CYP19A1 (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |