Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739220 | 0.89 | HRH3 (0.52) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9207731 | 0.88 | SIGMAR1 (0.43) | HRH3DRD4 | |
| SCHEMBL9740303 | 0.86 | HRH3 (0.60) | HRH3HTR2ACHRNB2CHRNA4CCR3 | |
| SCHEMBL9739552 | 0.85 | CHRNB2 (0.57) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9211609 | 0.79 | KDM4E (0.55) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9208504 | 0.79 | HRH2 (0.49) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9205094 | 0.78 | KDM4E (0.40) | KDM4EALDH1A1KMT2A | |
| SCHEMBL9740185 | 0.76 | HRH3 (0.51) | HRH3 | |
| SCHEMBL9740254 | 0.75 | HRH3 (0.44) | HRH3 | |
| SCHEMBL9739652 | 0.75 | ADRA1B (0.45) | HRH3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |