SCHEMBL9215528

SCHEMBL9215528

O=c1oc2ncccc2n1CCN1CCN(c2ccccc2)CC1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 7/20 0.59
HTR1A P08908 6/20 0.59
KCNH2 Q12809 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9219074 0.93 HTR1A (0.66) HTR7HTR1A
SCHEMBL9219564 0.93 HTR1A (0.69) HTR7HTR1A
SCHEMBL9216657 0.90 MEN1 (0.50) HTR7HTR1A
SCHEMBL9221444 0.86 SIGMAR1 (0.49)
SCHEMBL9219866 0.85 TMEM97 (0.49)
SCHEMBL9210834 0.84 DRD3 (0.58) HTR7HTR1AKCNH2
SCHEMBL9597086 0.84 TMEM97 (0.51)
SCHEMBL9218535 0.82 SLC18A3 (0.46) HTR7HTR1A
SCHEMBL9597365 0.82 HTR7 (0.65) HTR7HTR1A
SCHEMBL9646137 0.81 HTR1A (0.60) HTR7HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0487408-B1 Oxazolopyridine derivatives, process for their preparation and pharmaceutical compositions comprising the same ADIR (FR) 1995-06-21 EP claimed
US-5130311-A Analgesics or antiinflammatory agents ADIR ET COMPAGNIE (FR) 1992-07-14 US claimed
US-5242923-A Analgesics ADIR ET COMPAGNIE (FR) 1993-09-07 US disclosed
US-5130311-A Analgesics or antiinflammatory agents ADIR ET COMPAGNIE (FR) 1992-07-14 US disclosed