Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215381 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL9209660 | 0.78 | LMNA (0.53) | KDM4EALDH1A1HPGDRAB9APDE4A | |
| SCHEMBL9208527 | 0.77 | ADORA3 (0.53) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL9214081 | 0.76 | PTGER4 (0.44) | ALDH1A1KMT2AMEN1HPGDTSHR | |
| SCHEMBL3182112 | 0.76 | KDM4E (0.58) | KDM4EALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL9200035 | 0.75 | PSEN1 (0.50) | KDM4EALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL9208164 | 0.75 | P2RX4 (0.50) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9216893 | 0.75 | ALDH1A1 (0.48) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL9215327 | 0.75 | PGR (0.59) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL31606585 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0386722-B1 | Imidazoquinolone derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-07-26 | — | — | EP | disclosed |
| US-4994468-A | Bronchodilators, antiallergens | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0386722-A1 | Imidazoquinolone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-09-12 | — | — | EP | disclosed |