Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215058 | 0.82 | GPR119 (0.40) | EGLN2NPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9219561 | 0.81 | RAB9A (0.52) | KDM4ENPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9219234 | 0.79 | NPC1 (0.57) | EGLN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL9218594 | 0.78 | RAB9A (0.40) | KDM4ENPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9215740 | 0.77 | KMO (0.41) | KDM4ENPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9215456 | 0.77 | TTR (0.38) | KDM4ENPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9221437 | 0.77 | AHR (0.34) | KDM4ENPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9222661 | 0.74 | SIGMAR1 (0.40) | KDM4EPDE2ANPC1DPP4MEN1 | |
| SCHEMBL9216188 | 0.74 | RAB9A (0.36) | KDM4ENPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL8993213 | 0.74 | RAB9A (0.46) | KDM4ENPC1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |