SCHEMBL922045

SCHEMBL922045

N#Cc1cccc(Oc2ccc(CNC(=O)c3cccnc3N)cc2)c1

nearest known ligand 0.69

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.48
SCN9A Q15858 3/20 0.46
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
PDPK1 O15530 1/20 0.44
KLKB1 P03952 1/20 0.43
KLK1 P06870 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921085 0.91 MAPK8 (0.52) MAPK8SMN1; SMN2SCN9ALMNAHPGD
SCHEMBL920461 0.85 MAPK8 (0.67) MAPK8SMN1; SMN2LMNAHPGD
SCHEMBL920269 0.85 MAPK8 (0.53) MAPK8SMN1; SMN2LMNAHPGDPDPK1
SCHEMBL920462 0.85 MAPK8 (0.53) MAPK8SMN1; SMN2LMNAHPGD
SCHEMBL920714 0.85 MAPK8 (0.53) MAPK8SMN1; SMN2LMNAHPGD
SCHEMBL921271 0.85 HPGD (0.57) MAPK8SMN1; SMN2LMNAHPGD
SCHEMBL920561 0.85 MAPK8 (0.53) MAPK8SMN1; SMN2LMNAHPGDKLKB1
SCHEMBL921448 0.85 MAPK8 (0.53) MAPK8SMN1; SMN2LMNAHPGD
SCHEMBL920500 0.84 SCN9A (0.44) SMN1; SMN2SCN9APDPK1KLKB1KLK1
SCHEMBL921767 0.84 KLKB1 (0.48) MAPK8SMN1; SMN2SCN9APDPK1KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK8 2313/4885SMN1; SMN2 4796/4885SCN9A 1203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.