Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.41 |
| ▸ | CYP21A2 | P08686 | 4/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9224925 | 1.00 | ADRB2 (0.42) | ADRB2ADRB1ADRB3CYP17A1CYP21A2 | |
| SCHEMBL10680323 | 0.81 | JAK2 (0.50) | ADRB2ADRB1ADRB3KCNH2JAK2 | |
| SCHEMBL9219820 | 0.80 | LTA4H (0.50) | JAK2LMNASMN1; SMN2ALDH1A1TCF4 | |
| SCHEMBL9513748 | 0.80 | JAK2 (0.51) | ADRB2ADRB1ADRB3KCNH2CYP3A4 | |
| SCHEMBL9514747 | 0.78 | HTR1A (0.58) | KCNH2LMNASMN1; SMN2 | |
| SCHEMBL9513736 | 0.76 | POLB (0.49) | ADRB2ADRB1ADRB3KCNH2SMN1; SMN2 | |
| SCHEMBL6375438 | 0.75 | SPHK1 (0.60) | ADRB2ADRB1ADRB3KCNH2LMNA | |
| SCHEMBL10577329 | 0.74 | KMT2A (0.53) | MEN1KMT2A | |
| SCHEMBL9224604 | 0.73 | SPHK1 (0.51) | ADRB2ADRB1ADRB3KCNH2LMNA | |
| SCHEMBL2022249 | 0.71 | KCNH2 (0.78) | ADRB2ADRB1ADRB3KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | claimed |
| US-5405997-A | Stable against rapid metabolism | THE UPJOHN COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | disclosed |