Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 12/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302004 | 0.96 | LMNA (0.55) | LMNANR3C2NR3C1MGLLITGAL | |
| SCHEMBL7299793 | 0.84 | LMNA (0.59) | LMNANR3C2NR3C1ALDH1A1NPSR1 | |
| SCHEMBL9079122 | 0.83 | LMNA (0.50) | LMNANR3C2NR3C1MGLL | |
| SCHEMBL7301998 | 0.80 | LMNA (0.53) | LMNANR3C2NR3C1MGLLALDH1A1 | |
| SCHEMBL7298261 | 0.80 | LMNA (0.58) | LMNANR3C2NR3C1MGLL | |
| SCHEMBL7300845 | 0.80 | LMNA (0.58) | LMNANR3C2NR3C1MGLL | |
| SCHEMBL8544144 | 0.79 | LMNA (0.53) | LMNANR3C2NR3C1MGLLNPSR1 | |
| SCHEMBL7305405 | 0.74 | LMNA (0.51) | LMNANR3C2NR3C1ITGALALDH1A1 | |
| SCHEMBL7304686 | 0.73 | LMNA (0.48) | LMNANR3C2NR3C1MGLLALDH1A1 | |
| SCHEMBL7299161 | 0.72 | LMNA (0.71) | LMNANR3C2NR3C1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550125-A | BRAIN DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |