SCHEMBL9230696

SCHEMBL9230696

CCOC(=O)CN1C(=O)C(NC(=O)[C@@H](SC(C)=O)C(C)C)C=Cc2ccc(-c3ccccc3)cc21

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 4/20 0.39
CCKAR P32238 2/20 0.39
GAA P10253 1/20 0.34
MAPT P10636 2/20 0.34
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
LMNA P02545 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9228780 0.88 CCKBR (0.39) CCKBRCCKARGAAMAPTTSHR
SCHEMBL9226683 0.83 LMNA (0.36) CCKBRCCKARMAPTTSHRHTT
SCHEMBL9230332 0.78 CCKBR (0.38) CCKBRCCKARSMN1; SMN2LMNANPSR1
SCHEMBL9230692 0.73 MEN1 (0.38) CCKBRCCKARGAASMN1; SMN2LMNA
SCHEMBL8883034 0.73 MEN1 (0.38) CCKBRCCKARGAASMN1; SMN2LMNA
SCHEMBL9226680 0.72 ACE (0.52)
SCHEMBL9228102 0.71 P2RX4 (0.40) SMN1; SMN2LMNANPSR1ALDH1A1
SCHEMBL8881762 0.70 CCKBR (0.39) CCKBRCCKARGAAMAPTTSHR
SCHEMBL11118972 0.69 NFKB1 (0.46) CCKBRCCKARGAASMN1; SMN2LMNA
SCHEMBL9222085 0.67 ACE (0.54)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0671172-A1 AMINO ACID DERIVATIVE Eisai Co., Ltd. (JP) 1995-09-13 EP disclosed