Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9238396 | 0.86 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL9239495 | 0.78 | SMN1; SMN2 (0.43) | CYP3A4SMN1; SMN2MAPTELANEMMP8 | |
| SCHEMBL7420112 | 0.76 | LTA4H (0.42) | TOP2AALDH1A1MAPTCYP4F2CYP4A11 | |
| SCHEMBL8448307 | 0.75 | CYP4F2 (0.45) | CYP3A4CYP2D6CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL15387340 | 0.74 | ALDH1A1 (0.34) | CYP2C19SMN1; SMN2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4385060 | 0.73 | CYP1A2 (0.46) | CYP3A4CYP2D6CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL18381220 | 0.72 | CYP3A4 (0.45) | CYP3A4CYP2D6CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL27358871 | 0.72 | CYP3A4 (0.48) | CYP3A4CYP2D6CYP2C19SMN1; SMN2TOP2A | |
| SCHEMBL9238392 | 0.71 | GGT1 (0.47) | — | |
| SCHEMBL14423609 | 0.71 | PLA2G2A (0.43) | SMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675112-A1 | Imidazole-containing inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |