Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9268258 | 0.78 | ALDH1A1 (0.58) | KMT2ALMNAMAPTGAAHTT | |
| SCHEMBL21056124 | 0.78 | POLB (0.59) | POLBPKMKMT2ADRD2HTR2A | |
| SCHEMBL16919653 | 0.71 | ALDH1A1 (0.60) | POLBKMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL8188945 | 0.70 | HDAC8 (0.50) | PDCD1CD274 | |
| SCHEMBL3907243 | 0.70 | KDM4E (0.51) | POLBKMT2ADRD2HTR2AHTR2B | |
| SCHEMBL7791770 | 0.70 | GHSR (0.47) | DRD2HTR2ARAB9ASMN1; SMN2 | |
| SCHEMBL10363338 | 0.69 | POLB (0.58) | POLBPKMKMT2ADRD2HTR2A | |
| SCHEMBL30051979 | 0.68 | MAPT (0.67) | POLBPKMKMT2ADRD2HTR2A | |
| Lidamidine SCHEMBL637088 | 0.68 | PKM (0.58) | POLBPKMKMT2ADRD2HTR2A | |
| Benzoic Acid SCHEMBL21485061 | 0.68 | POLB (0.53) | POLBPKMKMT2ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |