Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249886 | 0.84 | MEN1 (0.39) | TOP2AMEN1KMT2ATDP1RET | |
| SCHEMBL346454 | 0.82 | CHEK1 (0.52) | MEN1KMT2ATDP1RETLMNA | |
| SCHEMBL29708057 | 0.82 | CHEK1 (0.52) | MEN1KMT2ATDP1RETLMNA | |
| SCHEMBL279082 | 0.80 | CHKA (0.41) | CHKAEGFRMEN1KMT2APDE5A | |
| SCHEMBL9251613 | 0.79 | APAF1 (0.40) | EGFRTDP1ALDH1A1 | |
| SCHEMBL10695407 | 0.78 | KMT2A (0.46) | TOP2ACHKAEGFRMEN1KMT2A | |
| SCHEMBL9101634 | 0.76 | TDP1 (0.37) | MEN1KMT2ATDP1RETLMNA | |
| SCHEMBL20109430 | 0.75 | SMN1; SMN2 (0.44) | CHKAEGFRMEN1KMT2ATDP1 | |
| SCHEMBL11521967 | 0.75 | ALDH1A3 (0.45) | MEN1KMT2ATDP1RETLMNA | |
| SCHEMBL9249935 | 0.74 | NR3C2 (0.38) | MEN1KMT2ATDP1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5395969-A | Charge transport or control agents; photoconductors; electrographic toners | ZENECA LIMITED (GB) | 1995-03-07 | — | — | US | disclosed |
| US-5278315-A | Phenylaminonaphthalyl hydrazone | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-11 | — | — | US | disclosed |