Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 8/20 | 0.41 |
| ▸ | TPSD1 | Q9BZJ3 | 8/20 | 0.41 |
| ▸ | TPSG1 | Q9NRR2 | 8/20 | 0.41 |
| ▸ | F2 | P00734 | 8/20 | 0.41 |
| ▸ | PLG | P00747 | 3/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | FURIN | P09958 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9254764 | 0.83 | EPHX1 (0.38) | MAPK1ALDH1A1LMNARAB9A | |
| SCHEMBL9247290 | 0.79 | TMPRSS15 (0.35) | F2ITGB3ITGA2BALDH1A1RAB9A | |
| SCHEMBL9254531 | 0.77 | TMPRSS15 (0.43) | PRSS1F2MAPTITGB3ITGA2B | |
| SCHEMBL9257176 | 0.74 | CSNK2A2 (0.43) | PRSS1F2ITGB3ITGA2BF10 | |
| SCHEMBL9257438 | 0.74 | ITGB3 (0.46) | PRSS1F2PLGPRSS2PRSS3 | |
| SCHEMBL9250531 | 0.72 | F2 (0.35) | PRSS1TPSAB1TPSD1TPSG1F2 | |
| SCHEMBL9254086 | 0.72 | F2 (0.39) | PRSS1F2PRSS2PRSS3ITGB3 | |
| SCHEMBL9255636 | 0.67 | TMPRSS15 (0.39) | PRSS1F2ITGB3ITGA2BALDH1A1 | |
| SCHEMBL9250922 | 0.67 | AHR (0.39) | ALDH1A1 | |
| SCHEMBL9253124 | 0.66 | F2 (0.45) | PRSS1F2ITGB3ITGA2BF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463071-A | Tetrazole derivatives; useful for inhibiting undesirable cell aggregation | DR. KARL THOMAE GMBH (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0525629-A2 | 5-membered heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |