Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 10/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | PKLR | P30613 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249207 | 0.85 | LMNA (0.39) | PKMPHGDHMGLLPKLRCA1 | |
| SCHEMBL10446594 | 0.69 | SMN1; SMN2 (0.42) | PKMALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL9246403 | 0.69 | MGLL (0.39) | PHGDHMGLLCA1CA2ALDH1A1 | |
| SCHEMBL9255521 | 0.69 | PHGDH (0.39) | PKMPHGDHMGLLPKLRCA1 | |
| SCHEMBL9255506 | 0.68 | KMT2A (0.58) | PHGDHMGLLALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9254069 | 0.68 | MGLL (0.38) | PHGDHMGLLCA1CA2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9248600 | 0.67 | ALDH1A1 (0.56) | PHGDHMGLLALDH1A1SMN1; SMN2 | |
| SCHEMBL9249526 | 0.66 | PHGDH (0.49) | PHGDHMGLLCA1CA2ALDH1A1 | |
| SCHEMBL9250088 | 0.65 | MPO (0.65) | PHGDHMGLLALDH1A1HPGD | |
| SCHEMBL9253292 | 0.64 | PHGDH (0.35) | PHGDHMGLLCA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446146-A | Treatment of liver disorders | NIPPON CHEMIPHAR CO., LTD. (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0326379-B1 | Therapeutic agent for liver disease and piperazine derivatives | NIPPON CHEMIPHAR CO (JP) | 1994-06-01 | — | — | EP | disclosed |
| US-5070089-A | INHIBITION OF LIPID PEROXIDATION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-12-03 | — | — | US | disclosed |
| EP-0326379-A2 | Therapeutic agent for liver disease and piperazine derivatives | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |