Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252253 | 0.95 | HDAC6 (0.46) | HDAC6HDAC1HDAC8NAMPTHDAC3 | |
| SCHEMBL9252697 | 0.90 | HDAC6 (0.42) | HDAC6HDAC1HDAC8CTSLCTSS | |
| SCHEMBL9246045 | 0.89 | HDAC6 (0.51) | HDAC6HDAC1HDAC8NAMPTHDAC3 | |
| SCHEMBL9253879 | 0.87 | HDAC6 (0.46) | HDAC6HDAC1HDAC8NAMPTCTSK | |
| SCHEMBL9255606 | 0.84 | MMP1 (0.39) | F2MMP1CTSLCTSSPTPN1 | |
| SCHEMBL9252204 | 0.79 | LNPEP (0.40) | HDAC6F2PTPN1ERAP2LNPEP | |
| SCHEMBL9252266 | 0.78 | ACE (0.38) | HDAC6HDAC1HDAC8F2NAMPT | |
| SCHEMBL9252518 | 0.78 | PRSS1 (0.46) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL9250758 | 0.74 | HDAC6 (0.52) | HDAC6HDAC1HDAC8F2NAMPT | |
| SCHEMBL9252703 | 0.74 | ENPP2 (0.39) | HDAC6CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |