Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252266 | 0.96 | ACE (0.38) | F2LNPEPKLKB1ROCK2ROCK1 | |
| SCHEMBL9252204 | 0.95 | LNPEP (0.40) | F2ERAP2LNPEPKLKB1PTPN1 | |
| SCHEMBL9252703 | 0.90 | ENPP2 (0.39) | CTSLCTSSCTSKITGB3ITGA2B | |
| SCHEMBL9246050 | 0.90 | HDAC6 (0.40) | F2LNPEPITGB3ITGA2BF10 | |
| SCHEMBL9253897 | 0.87 | LNPEP (0.38) | F2ERAP2LNPEPCTSKITGB3 | |
| SCHEMBL9255461 | 0.84 | HDAC6 (0.42) | MMP1F2ERAP2LNPEPKLKB1 | |
| SCHEMBL9252253 | 0.79 | HDAC6 (0.46) | ACE | |
| SCHEMBL9252518 | 0.75 | PRSS1 (0.46) | ITGB3ITGA2B | |
| SCHEMBL9252697 | 0.74 | HDAC6 (0.42) | CTSLCTSSCTSK | |
| SCHEMBL9246045 | 0.72 | HDAC6 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380729-A | Treatment or prevention of neurodegenerative disorders or neurotoxic injuries | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |