Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9246050 | 0.92 | HDAC6 (0.40) | LNPEPHDAC6HDAC1HDAC8NAMPT | |
| SCHEMBL9252266 | 0.91 | ACE (0.38) | LNPEPHDAC6HDAC1HDAC8NAMPT | |
| SCHEMBL9252204 | 0.87 | LNPEP (0.40) | LNPEPERAP2ERAP1HDAC6F2 | |
| SCHEMBL9255606 | 0.87 | MMP1 (0.39) | LNPEPERAP2CTSKF10F2 | |
| SCHEMBL9252703 | 0.85 | ENPP2 (0.39) | HDAC6CTSKMEN1KMT2AITGB3 | |
| SCHEMBL9253879 | 0.82 | HDAC6 (0.46) | LNPEPERAP2ERAP1HDAC6HDAC1 | |
| SCHEMBL9252253 | 0.73 | HDAC6 (0.46) | HDAC6HDAC1HDAC8NAMPT | |
| SCHEMBL9246045 | 0.73 | HDAC6 (0.51) | HDAC6HDAC1HDAC8NAMPT | |
| SCHEMBL9251384 | 0.71 | HDAC1 (0.49) | HDAC6HDAC1HDAC8NAMPTF10 | |
| SCHEMBL9251561 | 0.70 | PARP1 (0.43) | ALDH1A1KMT2AF10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |