Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 3/20 | 0.35 |
| ▸ | FNTB | P49356 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9266939 | 0.87 | MMP9 (0.38) | MAPK1ALDH1A1LMNA | |
| SCHEMBL9256495 | 0.77 | CYP1A2 (0.42) | — | |
| SCHEMBL9261597 | 0.76 | GABBR2 (0.51) | MAPTGABBR2GABBR1KDM4ERECQL | |
| SCHEMBL7655013 | 0.76 | MAPT (0.55) | MAPTGABBR2GABBR1FNTAFNTB | |
| SCHEMBL9259383 | 0.73 | MAPT (0.41) | MAPTGABBR2GABBR1FNTAFNTB | |
| SCHEMBL9261314 | 0.71 | PTGIR (0.42) | MAPTGABBR2GABBR1FNTAFNTB | |
| SCHEMBL9256395 | 0.71 | MAPT (0.47) | MAPTGABBR2GABBR1GAAFNTA | |
| SCHEMBL9257535 | 0.70 | MAPT (0.46) | MAPTGABBR2GABBR1HPGDKDM4E | |
| SCHEMBL9257785 | 0.70 | ALDH1A1 (0.42) | MAPTMAPK1HPGDGAAKDM4E | |
| SCHEMBL21273079 | 0.70 | GABBR2 (0.59) | MAPTGABBR2GABBR1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |