SCHEMBL9256674

SCHEMBL9256674

C=CCCCc1ccc(C(=O)Oc2ccc(F)c(F)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.41
ALDH1A1 P00352 1/20 0.41
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
THRB P10828 7/20 0.39
CYP4A11 Q02928 2/20 0.37
THRA P10827 5/20 0.36
CYP4F2 P78329 1/20 0.36
PTPN1 P18031 2/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
CYP3A4 P08684 1/20 0.35
MAPT P10636 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
F2 P00734 1/20 0.34
PRSS1 P07477 1/20 0.34
PRSS2 P07478 1/20 0.34
PRSS3 P35030 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16603415 0.87 MAOA (0.46) MAOAMAOBTHRBCYP4A11THRA
SCHEMBL9482558 0.86 ALDH1A1 (0.36) L3MBTL1ALDH1A1THRBCYP4A11THRA
SCHEMBL9256719 0.86 THRB (0.45) L3MBTL1ALDH1A1MAOBTHRBCYP4A11
SCHEMBL8052185 0.83 L3MBTL1 (0.35) L3MBTL1ALDH1A1THRBCYP4A11THRA
SCHEMBL9303397 0.83 KMT2A (0.47) L3MBTL1ALDH1A1MAOAMAOBTHRB
SCHEMBL9253512 0.82 ALDH1A1 (0.49) L3MBTL1ALDH1A1MAOAMAOBMEN1
SCHEMBL8913584 0.81 THRB (0.58) L3MBTL1ALDH1A1THRBCYP4A11THRA
SCHEMBL8923657 0.81 THRB (0.58) THRBTHRAMEN1KMT2ACYP3A4
SCHEMBL9303970 0.81 MAPT (0.53) ALDH1A1THRBCYP4A11CYP4F2KMT2A
SCHEMBL9256549 0.80 ADRB2 (0.45) MAOAMAOBPTPN1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5454974-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1995-10-03 US disclosed
US-5302317-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US disclosed
US-5230826-A HALOBENZENE LIQUID CRYSTALS HOFFMANN-LA ROCHE INC. (US) 1993-07-27 US disclosed