Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260421 | 0.89 | CHRM1 (0.43) | CHRM1KMT2AMEN1TSHRMAPT | |
| SCHEMBL9260959 | 0.84 | KMT2A (0.42) | KMT2AMEN1MAPTALDH1A1POLB | |
| SCHEMBL7163453 | 0.84 | KMT2A (0.59) | KMT2AMEN1MAPTALDH1A1POLB | |
| SCHEMBL9260110 | 0.83 | STS (0.42) | HTTCHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL9262369 | 0.83 | KMT2A (0.41) | KMT2AMEN1MAPTGABBR2GABBR1 | |
| SCHEMBL9256833 | 0.79 | TSHR (0.45) | HTTCHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL9257785 | 0.76 | ALDH1A1 (0.42) | HTTKMT2AMEN1TSHRMAPT | |
| SCHEMBL9253341 | 0.74 | MEN1 (0.47) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL9261597 | 0.74 | GABBR2 (0.51) | KMT2AMEN1TSHRMAPTALDH1A1 | |
| SCHEMBL7655013 | 0.73 | MAPT (0.55) | KMT2AMEN1MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |