Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.32 |
| ▸ | GCG | P01275 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9246913 | 0.91 | GCG (0.38) | SMN1; SMN2MGLLCXCR2GCGNPC1 | |
| SCHEMBL9255212 | 0.88 | PDK1 (0.33) | MAPTSMN1; SMN2NPC1HSD17B10PDK1 | |
| SCHEMBL9259482 | 0.87 | PDK1 (0.33) | MAPTSMN1; SMN2NPC1HSD17B10PDK1 | |
| SCHEMBL8863938 | 0.85 | TMPRSS15 (0.36) | MAPTSMN1; SMN2NPC1TLR8PDK1 | |
| SCHEMBL9251525 | 0.82 | MIF (0.37) | NPC1TLR8PDK1 | |
| SCHEMBL9250749 | 0.81 | ALOX5 (0.30) | PDK1 | |
| SCHEMBL9255067 | 0.81 | PDK1 (0.33) | MAPTSMN1; SMN2NPC1HSD17B10PDK1 | |
| SCHEMBL9257803 | 0.80 | MAPT (0.35) | MAPT | |
| SCHEMBL8863936 | 0.79 | CYP11B1 (0.43) | MAPTCXCR2NPC1PDK1LMNA | |
| SCHEMBL9251800 | 0.79 | PDK1 (0.36) | MAPTSMN1; SMN2GCGNPC1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463071-A | Tetrazole derivatives; useful for inhibiting undesirable cell aggregation | DR. KARL THOMAE GMBH (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0525629-A2 | 5-membered heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |