Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259482 | 0.91 | PDK1 (0.33) | PDK1NPC1PSEN1PSEN2APH1B | |
| SCHEMBL9251800 | 0.90 | PDK1 (0.36) | PDK1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8863938 | 0.89 | TMPRSS15 (0.36) | PDK1NPC1PSEN1PSEN2APH1B | |
| SCHEMBL9256865 | 0.88 | MAPT (0.33) | PDK1NPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9250749 | 0.85 | ALOX5 (0.30) | PDK1 | |
| SCHEMBL9251525 | 0.84 | MIF (0.37) | PDK1NPC1PSEN1PSEN2APH1B | |
| SCHEMBL9255067 | 0.83 | PDK1 (0.33) | PDK1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8863936 | 0.82 | CYP11B1 (0.43) | PDK1NPC1MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9257352 | 0.82 | PDK1 (0.36) | PDK1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL9254094 | 0.80 | F2 (0.37) | PDK1NPC1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463071-A | Tetrazole derivatives; useful for inhibiting undesirable cell aggregation | DR. KARL THOMAE GMBH (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0525629-A2 | 5-membered heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |