Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 4/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259482 | 0.89 | PDK1 (0.33) | PDK1RAB9ASMN1; SMN2ALOX5MAPT | |
| SCHEMBL9254094 | 0.87 | F2 (0.37) | PDK1RAB9ASMN1; SMN2MAPTUSP2 | |
| SCHEMBL9250749 | 0.86 | ALOX5 (0.30) | PDK1ALOX5 | |
| SCHEMBL9257621 | 0.84 | PDK1 (0.36) | PDK1 | |
| SCHEMBL9255212 | 0.83 | PDK1 (0.33) | PDK1RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL9254355 | 0.82 | PDK1 (0.35) | PDK1NPC1 | |
| SCHEMBL9256865 | 0.81 | MAPT (0.33) | PDK1SMN1; SMN2MAPTNPC1HSD17B10 | |
| SCHEMBL8863938 | 0.80 | TMPRSS15 (0.36) | PDK1RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL9257803 | 0.80 | MAPT (0.35) | MAPT | |
| SCHEMBL9254692 | 0.79 | F10 (0.34) | PDK1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463071-A | Tetrazole derivatives; useful for inhibiting undesirable cell aggregation | DR. KARL THOMAE GMBH (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0525629-A2 | 5-membered heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |