Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | SPNS2 | Q8IVW8 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248487 | 0.91 | AGER (0.38) | TLR8ITGB3ITGA2BSMN1; SMN2MAPT | |
| SCHEMBL9280389 | 0.87 | ITGB3 (0.35) | ITGB3ITGA2BNPC1RAB9A | |
| SCHEMBL9568422 | 0.86 | F2 (0.37) | ITGB3ITGA2BMAPT | |
| SCHEMBL9250808 | 0.82 | ITGB3 (0.36) | ITGB3ITGA2BMAPTNPC1 | |
| SCHEMBL9259191 | 0.82 | NQO2 (0.38) | ITGB3ITGA2BSMN1; SMN2MAPTNPC1 | |
| SCHEMBL8863938 | 0.78 | TMPRSS15 (0.36) | TLR8ITGB3ITGA2BSMN1; SMN2MAPT | |
| SCHEMBL9251260 | 0.78 | F10 (0.36) | SMN1; SMN2MAPT | |
| SCHEMBL9250591 | 0.77 | MIF (0.43) | ITGB3ITGA2BMAPTNPC1RAB9A | |
| SCHEMBL9247213 | 0.76 | ITGB3 (0.39) | ITGB3ITGA2B | |
| SCHEMBL9250761 | 0.76 | F2 (0.40) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463071-A | Tetrazole derivatives; useful for inhibiting undesirable cell aggregation | DR. KARL THOMAE GMBH (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0525629-A2 | 5-membered heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |