Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | F7 | P08709 | 2/20 | 0.51 |
| ▸ | GUSB | P08236 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8816568 | 0.81 | MAPT (0.61) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 | |
| SCHEMBL8818550 | 0.79 | MGAM (0.51) | MAPTPARP1GAA | |
| SCHEMBL2308775 | 0.73 | NPBWR1 (0.79) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 | |
| SCHEMBL31474756 | 0.72 | MMP13 (0.68) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 | |
| SCHEMBL28761269 | 0.72 | RAB9A (0.80) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 | |
| SCHEMBL3336091 | 0.72 | RAB9A (0.80) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 | |
| SCHEMBL2126513 | 0.71 | MAPT (0.74) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 | |
| SCHEMBL8817544 | 0.71 | MGAM (0.50) | MAPTRAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL31679090 | 0.71 | NPBWR1 (1.00) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 | |
| SCHEMBL2245102 | 0.71 | NPBWR1 (1.00) | MAPTRAB9ANPC1NPBWR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995007263-A1 | 1,2-DI(HETERO)ARYLBENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROSTACYCLIN (PGI2) MIMETICS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-03-16 | — | — | WO | disclosed |