Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 6/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259956 | 0.84 | LMNA (0.37) | CYP2C19KDM4EHTTSMN1; SMN2LMNA | |
| SCHEMBL9425991 | 0.84 | KLK5 (0.40) | CYP2C19KLK5F2TMPRSS15F7 | |
| SCHEMBL9260001 | 0.77 | F2 (0.37) | KLK5F2TMPRSS15F7PLG | |
| SCHEMBL6985069 | 0.72 | TMPRSS15 (0.36) | TMPRSS15PRSS1 | |
| SCHEMBL6978248 | 0.71 | ITGB3 (0.35) | TMPRSS15 | |
| SCHEMBL7361739 | 0.71 | CYP2C19 (0.67) | CYP2C19KLK5F2KDM4EHTT | |
| SCHEMBL9264762 | 0.69 | GSK3B (0.39) | KLK5F2TMPRSS15F7PLG | |
| SCHEMBL9425716 | 0.69 | F2 (0.37) | KLK5F2TMPRSS15F7HTT | |
| SCHEMBL9426346 | 0.68 | F2 (0.43) | CYP2C19KLK5F2KDM4EHTT | |
| SCHEMBL6979099 | 0.67 | ITGB3 (0.40) | KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378727-A | ADMINISTERING TO MAMMALS | G. D. SEARLE & CO. (US) | 1995-01-03 | — | — | US | disclosed |
| US-5254573-A | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors | MONSANTO COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0539343-A1 | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors | MONSANTO COMPANY (US) | 1993-04-28 | — | — | EP | disclosed |