Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CSK | P41240 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92553 | 0.91 | LMNA (0.44) | LMNARIPK1MAPTSMN1; SMN2TP53 | |
| SCHEMBL10273060 | 0.91 | LMNA (0.42) | LMNATHRBRIPK1MAPTSMN1; SMN2 | |
| SCHEMBL92610 | 0.90 | LMNA (0.43) | LMNATHRBMAPTSMN1; SMN2MEN1 | |
| SCHEMBL10273949 | 0.88 | KDM4E (0.50) | LMNARIPK1MAPTALDH1A1KDM4E | |
| SCHEMBL92542 | 0.85 | LMNA (0.44) | LMNARIPK1MAPTSMN1; SMN2TP53 | |
| SCHEMBL10273059 | 0.81 | LMNA (0.43) | LMNATHRBMAPTSMN1; SMN2MEN1 | |
| SCHEMBL93047 | 0.80 | RAB9A (0.43) | LMNAMAPTSMN1; SMN2POLBTDP1 | |
| SCHEMBL92552 | 0.77 | KDM4E (0.53) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL91588 | 0.77 | KDM4E (0.53) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL10273937 | 0.77 | THRB (0.56) | LMNATHRBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129366-B2 | VLA-4 inhibitory drug | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | VCAM1, ITGB4, ITGA4 | LMNA 1466/4885THRB 940/4885RIPK1 4123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.