Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.55 |
| ▸ | WNT3A | P56704 | 2/20 | 0.55 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | USP5 | P45974 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950960 | 0.86 | TAS1R3 (0.57) | ALDH1A1POLBMAPTCTNNB1WNT3A | |
| SCHEMBL29923058 | 0.85 | CTNNB1 (0.73) | ALDH1A1CYP1A2HPGDCYP2C19HSD17B10 | |
| SCHEMBL1527427 | 0.85 | CTNNB1 (0.73) | ALDH1A1CYP1A2HPGDCYP2C19HSD17B10 | |
| SCHEMBL4257689 | 0.85 | KMT2A (0.55) | ALDH1A1CYP1A2HPGDCYP2C19HSD17B10 | |
| SCHEMBL5188941 | 0.83 | ALDH1A1 (0.59) | ALDH1A1CYP1A2HPGDCYP2C19HSD17B10 | |
| SCHEMBL5495178 | 0.83 | CTNNB1 (0.60) | ALDH1A1CYP1A2HPGDCYP2C19HSD17B10 | |
| SCHEMBL30449245 | 0.82 | TAS1R3 (0.45) | ALDH1A1CYP1A2HPGDCYP2C19POLB | |
| SCHEMBL29032173 | 0.82 | TAS1R3 (0.45) | ALDH1A1CYP1A2HPGDCYP2C19POLB | |
| SCHEMBL6136939 | 0.82 | TAS1R3 (0.53) | ALDH1A1CYP1A2CYP2C19POLBMAPT | |
| SCHEMBL12780432 | 0.82 | MEN1 (0.59) | ALDH1A1CYP1A2HPGDCYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240182452-A1 | 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | BAYER AKTIENGESELLSCHAFT (DE) | 2024-06-06 | — | — | US | disclosed |
| US-11897867-B2 | 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer | BAYER AKTIENGESELLSCHAFT (DE) | 2024-02-13 | — | — | US | disclosed |
| CN-116249691-A | Bicyclic derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-09 | — | — | CN | disclosed |
| EP-3661917-B1 | 6-((3-TRIFLUOROMETHYL)PHENYL)-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | BAYER AG (DE) | 2022-05-11 | — | — | EP | disclosed |
| US-20210077431-A1 | N-(2-(SUBSTITUTED-NAPHTH-1-YL)ETHYL) SUBSTITUTED AMIDE COMPOUND, PREPARATION AND USES THEREOF | BEIJING GREATWAY PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2021-03-18 | — | — | US | disclosed |
| US-20200247783-A1 | 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | US | disclosed |
| EP-3661917-A1 | 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | Bayer Aktiengesellschaft (DE) | 2020-06-10 | — | — | EP | disclosed |
| WO-2019025554-A1 | 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | BAYER AKTIENGESELLSCHAFT (DE) | 2019-02-07 | — | — | WO | disclosed |
| US-5428168-A | Substituted butyrolactol ether derivative | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-06-27 | — | — | US | disclosed |
| EP-0527817-A1 | GAMMA-BUTYROLACTOL ETHER DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991017157-A1 | GAMMA-BUTYROLACTOL ETHER DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1991-11-14 | — | — | WO | disclosed |
| US-4052395-A | AGRICULTURAL FUNGICIDAL COMPOSITIONS CONTAINING 6-(SUBSTITUTED PHENYL)-PYRIDAZINONES AND SAID PYRIDAZINONES | SANKYO COMPANY LIMITED (JA) | 1977-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240182452-A1 | 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | PDE3A, PDE3B, PDE5A | ALDH1A1 118/4885CYP1A2 365/4885HPGD 71/4885 |
| US-20200247783-A1 | 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | PDE3B, PDE3A, PDE5A | ALDH1A1 53/4885CYP1A2 262/4885HPGD 272/4885 |
| US-11897867-B2 | 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer | PDE3B, PDE3A, PDE5A | ALDH1A1 53/4885CYP1A2 262/4885HPGD 272/4885 |
| US-20210077431-A1 | N-(2-(SUBSTITUTED-NAPHTH-1-YL)ETHYL) SUBSTITUTED AMIDE COMPOUND, PREPARATION AND USES THEREOF | MTNR1A, HTR2C, MTNR1B | ALDH1A1 2141/4885CYP1A2 291/4885HPGD 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.