Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | RRM1 | P23921 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9283625 | 0.99 | TOP2A (0.44) | TOP2AKDM4EGAAL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL9153136 | 0.83 | KDM4E (0.54) | KDM4EGAAL3MBTL1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9149882 | 0.79 | TOP2A (0.51) | TOP2AKDM4EGAAL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL9149017 | 0.79 | KDM4E (0.43) | KDM4EGAAL3MBTL1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9251328 | 0.78 | XDH (0.53) | KDM4EGAAL3MBTL1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9459226 | 0.78 | XDH (0.53) | KDM4EGAAL3MBTL1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9149205 | 0.76 | CTRC (0.38) | KDM4EL3MBTL1MAPTLMNASMN1; SMN2 | |
| Iodide SCHEMBL9273050 | 0.76 | GAA (0.43) | KDM4EGAAL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL10628276 | 0.74 | L3MBTL1 (0.64) | TOP2AKDM4EGAAL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL9459288 | 0.74 | RAB9A (0.53) | KDM4EGAAMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995021822-A1 | PYRIDINIUM COMPOUNDS | GEORGIA TECH RESEARCH CORPORATION (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5290942-A | Acetylcholinesterase inhibitors | GEORGIA TECH RESEARCH CORPORATION (US) | 1994-03-01 | — | — | US | disclosed |
| US-5206371-A | Acetylcholinesterase inhibitor | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-04-27 | — | — | US | disclosed |
| US-5180831-A | Acetylcholinesterase Inhibitors | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-01-19 | — | — | US | disclosed |