SCHEMBL927344

SCHEMBL927344

Nc1ccc(S(=O)(=O)c2ccc(N)c(N)c2N)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 7/20 0.58
TSHR P16473 3/20 0.58
LMNA P02545 1/20 0.58
MPO P05164 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2C9 P11712 1/20 0.58
ALDH1A1 P00352 2/20 0.55
PKM P14618 2/20 0.55
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
CA1 P00915 4/20 0.45
CA2 P00918 4/20 0.45
CA12 O43570 3/20 0.45
CA9 Q16790 3/20 0.45
CA14 Q9ULX7 2/20 0.45
CA4 P22748 2/20 0.45
USP2 O75604 1/20 0.45
CA6 P23280 1/20 0.45
CA5A P35218 1/20 0.45
CA7 P43166 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3291029 0.84 HTR6 (0.62) HTR6LMNAALDH1A1PKMKMT2A
SCHEMBL17774709 0.78 HTR6 (0.62) HTR6TSHRLMNAMPOCYP3A4
SCHEMBL1703357 0.78 HTR6 (0.60) HTR6TSHRLMNAMPOCYP3A4
SCHEMBL8003877 0.77 HTR6 (0.54) HTR6TSHRLMNAMPOCYP3A4
SCHEMBL11079690 0.77 MEN1 (0.55) HTR6TSHRLMNAMPOCYP3A4
SCHEMBL26294642 0.77 HTR6 (0.53) HTR6TSHRLMNAALDH1A1PKM
SCHEMBL324893 0.75 HTR6 (1.00) HTR6TSHRLMNAMPOCYP3A4
Dapsone SCHEMBL21428 0.75 HTR6 (1.00) HTR6TSHRLMNAMPOCYP3A4
Dapsone SCHEMBL1219599 0.75 HTR6 (1.00) HTR6TSHRLMNAMPOCYP3A4
Dapsone SCHEMBL5055312 0.75 HTR6 (1.00) HTR6TSHRLMNAMPOCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0145164-B1 PROCESS FOR IMPROVING MOISTURE RESISTANCE OR EPOXY RESINS BY ADDITION OF CHROMIUM IONS NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1987-03-04 EP claimed
EP-0145164-A1 Process for improving moisture resistance or epoxy resins by addition of chromium ions NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1985-06-19 EP claimed
US-4510277-A AEROSPACE APPLICATIONS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1985-04-09 US claimed
WO-2014031923-A1 COATED SUBSTRATES AND METHODS FOR PRODUCING THE SAME MILLIKEN & COMPANY (US) 2014-02-27 WO disclosed
US-20140058026-A1 COATED SUBSTRATES AND METHODS FOR PRODUCING THE SAME MILLIKEN & COMPANY (US) 2014-02-27 US disclosed
US-20110003955-A1 Imide Oligomer And Polyimide Resin Obtained By Thermal Curing Thereof DAIWA CAN COMPANY (JP) 2011-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110003955-A1 Imide Oligomer And Polyimide Resin Obtained By Thermal Curing Thereof PUF60, SMARCC2, SMARCA4 HTR6 4169/4885TSHR 4511/4885LMNA 3975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.