Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366245 | 0.85 | ALDH1A1 (0.42) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL9373748 | 0.82 | DPP4 (0.36) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL2482119 | 0.72 | DPP4 (0.50) | CA12CA1CA2CA9PDCD1 | |
| SCHEMBL7343883 | 0.72 | CA2 (0.41) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL9717406 | 0.71 | PDCD1 (0.47) | ADORA3ADORA2AADORA1PDCD1CD274 | |
| SCHEMBL29699190 | 0.71 | PDCD1 (0.47) | ADORA3ADORA2AADORA1PDCD1CD274 | |
| SCHEMBL7369396 | 0.71 | NPC1 (0.38) | CA12CA1CA2CA9LMNA | |
| SCHEMBL5145167 | 0.70 | SLC6A2 (0.54) | CA12CA1CA2CA9LMNA | |
| SCHEMBL17697636 | 0.70 | PDCD1 (0.55) | PDCD1CD274MYCHTR7SMN1; SMN2 | |
| SCHEMBL8029374 | 0.70 | CA12 (0.38) | CA12CA1CA2CA9PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640084-A4 | 6-AMINO SUBSTITUTED IMIDAZO 4,5-b]PYRIDINES AS ANGIOTENSIN II ANTAGONISTS. | MERCK & CO INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0640084-A1 | 6-AMINO SUBSTITUTED IMIDAZO 4,5-b]PYRIDINES AS ANGIOTENSIN II ANTAGONISTS | MERCK & CO. INC. (US) | 1995-03-01 | — | — | EP | disclosed |
| EP-0586513-A1 | ACIDIC ARALKYL TRIAZOLE DERIVATIVES ACTIVE AS ANGIOTENSIN II ANTAGONISTS | MERCK & CO. INC. (US) | 1994-03-16 | — | — | EP | disclosed |