Sugi Predict

Sugi Predict / Compounds / SCHEMBL9277352

SCHEMBL9277352

SCHEMBL9277352

Cc1cc(C2CC2)ccn1

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 1/20 0.50
▸ UHRF1 Q96T88 1/20 0.48
▸ TLR7 Q9NYK1 12/20 0.46
▸ TLR9 Q9NR96 11/20 0.46
▸ TLR8 Q9NR97 11/20 0.46
▸ USP30 Q70CQ3 1/20 0.42
▸ DYRK1A Q13627 1/20 0.40
▸ PROKR1 Q8TCW9 1/20 0.39
▸ HTR2C P28335 1/20 0.36
▸ LNPEP Q9UIQ6 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyanide SCHEMBL27912025 0.94 IDO1 (0.47) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL12093743 0.92 IDO1 (0.45) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL12093732 0.92 IDO1 (0.45) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL21187181 0.91 IDO1 (0.45) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL22730013 0.91 IDO1 (0.48) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL23660437 0.91 IDO1 (0.48) IDO1UHRF1TLR7TLR9TLR8
Bicarbonate SCHEMBL9280862 0.91 IDO1 (0.54) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL22730012 0.91 IDO1 (0.48) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL30209450 0.91 IDO1 (0.45) IDO1UHRF1TLR7TLR9TLR8
SCHEMBL22402327 0.90 IDO1 (0.44) IDO1UHRF1TLR7TLR9TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105980387-B Serine/threonine kinase inhibitor 阵列生物制药公司 2019-04-19 — — CN claimed
EP-3089980-B1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2018-01-31 — — EP claimed
US-9670208-B2 Serine/threonine kinase inhibitors ARRAY BIOPHARMA INC. (US) 2017-06-06 — — US claimed
EP-3089980-A1 SERINE/THREONINE KINASE INHIBITORS Array Biopharma, Inc. (US) 2016-11-09 — — EP claimed
US-20160304519-A1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2016-10-20 — — US claimed
WO-2015103137-A1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2015-07-09 — — WO claimed
US-20240287063-A1 METHIONINE ADENOSYLTRANSFERASE 2A INHIBITOR NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD. (CN) 2024-08-29 — — US disclosed
CN-117412967-A Methionine adenosine transferase 2A inhibitors 南京正大天晴制药有限公司 2024-01-16 — — CN disclosed
US-11746100-B2 Cycloalkyl pyrimidines as ferroportin inhibitors GLOBAL BLOOD THERAPEUTICS, INC. (US) 2023-09-05 — — US disclosed
US-20230226074-A1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2023-07-20 — — US disclosed
US-20200287143-A1 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2020-09-10 — — US disclosed
WO-2019149260-A1 PYRIDAZINOL COMPOUND, DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 2019-08-08 — — WO disclosed
CN-105980387-B Serine/threonine kinase inhibitor 阵列生物制药公司 2019-04-19 — — CN disclosed
EP-2500345-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE Dainippon Sumitomo Pharma Co., Ltd. (JP) 2012-09-19 — — EP disclosed
US-20120225876-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2012-09-06 — — US disclosed
US-20120225876-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2012-09-06 — — US disclosed
WO-2012072200-A1 3-HETARYL-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS MERCK PATENT GMBH (DE) 2012-06-07 — — WO disclosed
WO-2011059021-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE 大日本住友製薬株式会社 (JP) 2011-05-19 — — WO disclosed
CN-1823083-B Lincomycin derivatives with antimicrobial activity VICURON PHARM INC 2010-05-26 — — CN disclosed
CN-1823083-A Novel lincomycin derivatives with antimicrobial activity VICURON PHARM INC (US) 2006-08-23 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287063-A1 METHIONINE ADENOSYLTRANSFERASE 2A INHIBITOR MAT2A, MAT2B, MAT1A IDO1 464/4885UHRF1 600/4885TLR7 4758/4885
US-20230226074-A1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS SLC40A1, HAMP, SLC19A1 IDO1 1081/4885UHRF1 3004/4885TLR7 3883/4885
US-20200287143-A1 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME SCO2, RER1, ORC3 IDO1 334/4885UHRF1 790/4885TLR7 4096/4885
US-11746100-B2 Cycloalkyl pyrimidines as ferroportin inhibitors HAMP, SLC40A1, FANCI IDO1 342/4885UHRF1 4316/4885TLR7 4421/4885
US-20120225876-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE HDAC10, HDAC11, HDAC1 IDO1 1948/4885UHRF1 2963/4885TLR7 1473/4885
US-20160304519-A1 SERINE/THREONINE KINASE INHIBITORS TTBK1, MAP3K1, TNNI3K IDO1 3394/4885UHRF1 3673/4885TLR7 3380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.