Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11169076 | 0.82 | MAPT (0.49) | ALDH1A1MAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL12824120 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAOBAOC3SMN1; SMN2HRH3 | |
| SCHEMBL8247256 | 0.80 | MAPT (0.54) | ALDH1A1SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL12622681 | 0.80 | LMNA (0.53) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL656941 | 0.80 | ALOX15 (0.59) | ALDH1A1MAOBAOC3SMN1; SMN2HRH3 | |
| SCHEMBL10931456 | 0.80 | MAPK1 (0.59) | ALDH1A1SMN1; SMN2AR | |
| SCHEMBL2173764 | 0.80 | PSEN1 (0.52) | ALDH1A1MAOBAOC3SMN1; SMN2HRH3 | |
| SCHEMBL13279565 | 0.79 | MEN1 (0.63) | ALDH1A1MAOBAOC3SMN1; SMN2HRH3 | |
| SCHEMBL934362 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL12622683 | 0.79 | SMN1; SMN2 (0.71) | ALDH1A1MAOBAOC3SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2022-12-13 | — | — | US | disclosed |
| US-11174231-B1 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2021-11-16 | — | — | US | disclosed |
| EP-2646418-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PARASITIC AGENTS | BAYER IP GMBH (DE) | 2017-10-04 | — | — | EP | disclosed |
| EP-2646418-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PARASITIC AGENTS | BAYER IP GMBH (DE) | 2017-10-04 | — | — | EP | disclosed |
| US-9241487-B2 | Pyrimidine derivatives and use thereof as pesticides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-26 | — | — | US | disclosed |
| US-9241487-B2 | Pyrimidine derivatives and use thereof as pesticides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-26 | — | — | US | disclosed |
| US-9241487-B2 | Pyrimidine derivatives and use thereof as pesticides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-26 | — | — | US | disclosed |
| US-20140031373-A1 | PYRIMIDINE DERIVATIVES AND USE THEREOF AS PESTICIDES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-30 | — | — | US | disclosed |
| US-20140031373-A1 | PYRIMIDINE DERIVATIVES AND USE THEREOF AS PESTICIDES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-30 | — | — | US | disclosed |
| US-20140031373-A1 | PYRIMIDINE DERIVATIVES AND USE THEREOF AS PESTICIDES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-30 | — | — | US | disclosed |
| EP-2646418-A1 | PYRIMIDINE DERIVATIVES AND USE THEREOF AS PESTICIDES | Bayer Intellectual Property GmbH (DE) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012072547-A1 | PYRIMIDINE DERIVATIVES AND USE THEREOF AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012072547-A1 | PYRIMIDINE DERIVATIVES AND USE THEREOF AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174231-B1 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | ALDH1A1 2252/4885MAOB 2548/4885AOC3 2046/4885 |
| US-20140031373-A1 | PYRIMIDINE DERIVATIVES AND USE THEREOF AS PESTICIDES | TYMP, TYMS, UMPS | ALDH1A1 2374/4885MAOB 718/4885AOC3 2083/4885 |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | ALDH1A1 2252/4885MAOB 2548/4885AOC3 2046/4885 |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSL, CTSV | ALDH1A1 1863/4885MAOB 1780/4885AOC3 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.