Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.46 |
| ▸ | FABP7 | O15540 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31419531 | 1.00 | KMT2A (0.66) | KMT2AEPHX2CASP3FABP5FABP7 | |
| Hydrochloric Acid SCHEMBL31419532 | 0.99 | KMT2A (0.64) | KMT2AEPHX2CASP3FABP5FABP7 | |
| SCHEMBL8236471 | 0.92 | KMT2A (0.70) | KMT2AEPHX2 | |
| SCHEMBL4572008 | 0.90 | KMT2A (0.73) | KMT2AEPHX2 | |
| SCHEMBL7132449 | 0.89 | KMT2A (0.75) | KMT2AEPHX2 | |
| SCHEMBL30733150 | 0.88 | KMT2A (0.61) | KMT2AEPHX2CASP3FABP5FABP7 | |
| SCHEMBL1770756 | 0.88 | KMT2A (0.61) | KMT2AEPHX2CASP3FABP5FABP7 | |
| SCHEMBL12291373 | 0.88 | KMT2A (0.62) | KMT2AEPHX2CASP3FABP5FABP7 | |
| SCHEMBL4740795 | 0.87 | KMT2A (0.64) | KMT2AEPHX2CASP3FABP5FABP7 | |
| SCHEMBL18376140 | 0.87 | KMT2A (0.64) | KMT2AEPHX2CASP3FABP5FABP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648315-B2 | Silvestrol antibody-drug conjugates and methods of use | GENENTECH, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| EP-3515880-B1 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF ENCODED LIBRARIES | HITGEN INC (CN) | 2023-05-10 | — | — | EP | disclosed |
| WO-2021113528-A1 | MODULATORS OF PROGRAMMED DEATH-LIGAND-1 AND/OR PROGRAMMED DEATH-LIGAND-2 | SOUTHERN RESEARCH INSTITUTE (US) | 2021-06-10 | — | — | WO | disclosed |
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-12-07 | — | — | US | disclosed |
| WO-2016196393-A2 | AUTOPHAGY-INHIBITING COMPOUNDS AND USES THEREOF | PRESAGE BIOSCIENCES, INC. (US) | 2016-12-08 | — | — | WO | disclosed |
| US-9296758-B2 | 2-quinolinyl-acetic acid derivatives as HIV antiviral compounds | GILEAD SCIENCES, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. | 2016-03-10 | — | — | US | disclosed |
| EP-2646454-B1 | 7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2015-07-08 | — | — | EP | disclosed |
| US-8771612-B2 | Photoresponsive gas-generating material, micropump and microfluid device | SEKISUI CHEMICAL CO., LTD. (JP) | 2014-07-08 | — | — | US | disclosed |
| US-20140142044-A1 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | The United States of America, as represented by the Secretary, Department of Health & Human Servic (US) | 2014-05-22 | — | — | US | disclosed |
| US-20130210801-A1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-8129505-B2 | Formed by catalytic polymerization; antibody conjugates | UCB PHARMA S.A. (BE) | 2012-03-06 | — | — | US | disclosed |
| US-20120045393-A1 | LHRH-II PEPTIDE ANALOGS | BRACCO IMAGING SPA (IT) | 2012-02-23 | — | — | US | disclosed |
| WO-2011091086-A1 | NOVEL REAGENTS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION | SIRIGEN INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| US-20110014096-A1 | PHOTORESPONSIVE GAS-GENERATING MATERIAL, MICROPUMP AND MICROFLUID DEVICE | SEKISUI CHEMICAL CO., LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| US-7850947-B2 | Gastrin releasing peptide compounds | BRACCO IMAGING S.P.A. (IT) | 2010-12-14 | — | — | US | disclosed |
| US-20080220005-A1 | Comb Polymers | UCB PHARMA S.A. (BE) | 2008-09-11 | — | — | US | disclosed |
| US-20070179100-A1 | Protected monomers | ALNYLAM PHARMACEUTICALS, INC. | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | SHBG, EPCAM, ITGAV | KMT2A 503/4885EPHX2 774/4885CASP3 3092/4885 |
| US-20140142044-A1 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | PLK1, PLK4, PLK3 | KMT2A 2194/4885EPHX2 2190/4885CASP3 3070/4885 |
| US-11648315-B2 | Silvestrol antibody-drug conjugates and methods of use | SHBG, EPCAM, ITGAV | KMT2A 503/4885EPHX2 774/4885CASP3 3092/4885 |
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | EHMT1, EHMT2, HNMT | KMT2A 23/4885EPHX2 2164/4885CASP3 3713/4885 |
| US-20120045393-A1 | LHRH-II PEPTIDE ANALOGS | LHCGR, GNRHR, FSHR | KMT2A 510/4885EPHX2 1883/4885CASP3 4438/4885 |
| US-20080220005-A1 | Comb Polymers | C9, F13B, PYM1 | KMT2A 1777/4885EPHX2 315/4885CASP3 2347/4885 |
| US-20070179100-A1 | Protected monomers | PCNA, POLN, PARP1 | KMT2A 1569/4885EPHX2 4321/4885CASP3 1082/4885 |
| US-20130210801-A1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | NFATC1, ACIN1, ARF1 | KMT2A 1975/4885EPHX2 4226/4885CASP3 1661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.