Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517218 | 0.87 | HTR1A (0.42) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9514774 | 0.85 | HTR1A (0.42) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9603353 | 0.83 | HTR2A (0.48) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9516233 | 0.81 | ALDH1A1 (0.42) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9228149 | 0.78 | HTR1A (0.50) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9514297 | 0.74 | HTR1A (0.39) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9517255 | 0.73 | SMN1; SMN2 (0.50) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL23743302 | 0.73 | HTR2A (0.75) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL20970870 | 0.73 | HTR2A (0.75) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL29527215 | 0.73 | HTR2A (0.75) | HTR1AHTR2AHTR2BHTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515462-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1995-05-31 | — | — | EP | claimed |
| US-5126363-A | Central nervous system disorders | NOVO NORDISK A/S (DK) | 1992-06-30 | — | — | US | claimed |
| EP-0515462-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1992-12-02 | — | — | EP | disclosed |
| US-5126363-A | Central nervous system disorders | NOVO NORDISK A/S (DK) | 1992-06-30 | — | — | US | disclosed |
| WO-1991012252-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-08-22 | — | — | WO | disclosed |